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from the latex of Calophyllum teysmanni var inophyllolide17 A total of 14 analogs were synthesized and tested by the NCI primary anti-HIV evaluation using XTT assay, whereas no compounds exhibited anti-HIV activity superior to the two natural lead products (1 and 15) Some structure activity requirements were apparent from the relative anti-HIV potencies of the various analogs Reduction of the 7,8ole nic bond indicated only a slight change in potency, and a hetero atom is required at C12, for activity such as ( )-12-oxo-calanolide B and ( )-12-oxocalanolide A still showed antiviral activity Zembower et al27 prepared a series of racemic structural analogs of ( )-calanolide A focused on the modi cation of the trans-10,11-dimethyldihydropyran-12-ol ring (ring C) and evaluated their anti-HIV activity using a CEM-SS cytoprotection assay. asp.net gs1 128 EAN - 128 ASP . NET Control - EAN - 128 barcode generator with free ...
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